In addition, the methylation of multiple genes (vimentin, NDRG4, BMP3, and TFPI2) combine with KRAS mutations in stool DNA were reported by Ahlquist et al., this test was able to detect CRC and precancerous adenoma with sensitivities of 85 and 54%, respectively, at a specificity of 90% [42]. The gene discussed is BMP3; the disease is colorectal carcinoma.