According to the results of multivariable logistic regression and multivariable Cox regression analyses, the homogeneous lung metastasis risk and prognostic factors in CRC were older age, unmarried status, uninsured status, poor histological differentiation, more lymphatic metastasis, CEA positivity, liver metastasis, bone metastasis, and brain metastasis. The gene discussed is CEACAM5; the disease is colorectal carcinoma.