The results showed that the expressions of NG2, CC-1, and MBP in offspring rats were significantly increased after prenatal treatment of PSB0788, indicating that PSB0788 could increase the level of OPCs and mature oligodendrocytes, thus alleviating the symptoms of demyelination caused by infection, and improving the adverse effects of prenatal inflammation on offspring cerebral white matter. The gene discussed is MBP; the disease is infection.