Pro-inflammatory cytokines such as IL-1β and TNF-α influenced on the myelin sheath by killing OPCs and inhibited the maturation of oligodendrocytes [43–45].In the present study, PVL model, disturbed the myelination process indicated by a decrease in the expression of NG2, CC-1 and MBP. Here, TNF is linked to periventricular leukomalacia.