Also, the A/L ratio was shown to be a stronger correlate to IR than adiponectin or leptin alone [25], an independent predictor of insulin sensitivity (IS) in women with moderate obesity [26] and men presenting obesity without [24] or with MetS [27], glucose intolerance [28] or T2D [25]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.