For example, in a retrospective study of 472 urology eConsults, Chertack et al [68] found that only 23% of patients referred for renal cysts required a face-to-face consultation compared with 80% (24/30) of patients with an elevated prostate-specific antigen (PSA), confirmed in another study (89% (42/47) of elevated PSA cases and after further workup in 11% (5/47) of cases [67]). The gene discussed is KLK3; the disease is cystic kidney disease.