In our previous project regarding hypothalamic inflammation, we found an association of Parasutterella with the MRI density in the hypothalamus in severe obese subjects.6 This is of interest since in the present study Parasutterella was associated with obesity and type 2 diabetes, but not with systemic inflammatory markers like IL-6 and CRP in the periphery. This evidence concerns the gene CRP and obesity due to melanocortin 4 receptor deficiency.