NLRP3 and neoplasm: 2 Compared with the KYSE150 + Fn and KYSE150 + Fn + CDDP groups, NSG mice in the KYSE150-N + Fn and KYSE150-N + Fn + CDDP groups had significantly reduced tumour-forming ability (p < 0.05), suggesting that NLRP3 knockdown could significantly inhibit the malignant proliferation of tumours.