In addition, 45 and 17 target genes of hsa-miR-16-5p and hsa-miR-451a, possibly related to TB development, from the mitogen-activated protein kinase (MAPK), mammalian (mechanistic) target of rapamycin (mTOR), and phosphatidylinositol 3′-kinase–Akt (PI3K-Akt) signaling pathways were selected for miRNA-gene network construction. This evidence concerns the gene AKT1 and tuberculosis.