In these studies, we utilize two previously described DS mouse models,11,24,25 and demonstrate that AAV-mediated upregulation of SCN1A with AAV9-REGABA-eTFSCN1A increases SCN1A transcripts specifically within GABAergic inhibitory interneurons, prolongs survival, and reduces spontaneous seizures and HTS. Here, SCN1A is linked to Dravet syndrome.