Adipose-derived stromal cells isolated from breast tissue from patients with obesity led to reduced sensitivity to the aromatase inhibitor, anastrozole, when co-cultured with MCF-7 cells in a 3D organotypic breast cancer model compared to adipose-derived stromal cells isolated from women with a healthy range BMI [47]. The gene discussed is CYP19A1; the disease is obesity due to melanocortin 4 receptor deficiency.