By univariate Cox regression analysis, the use of antiviral therapy, AFP > 10 ng/ml and sCTLA‐4 > 9 ng/ml were predictors of early LR (Table 3) while baseline TNM stage, use of antiviral therapy, AFP > 10 ng/ml and sCTLA‐4 > 9 ng/ml were predictors of early IHM (Table 4). The gene discussed is AFP; the disease is invasive hydatidiform mole.