Platelet involvement in arterial thrombosis (Figure 4) stems from its ability to undergo adhesion to exposed vWF and collagen at the site of endothelial damage, activation by multiple autocrine and paracrine agonists (e.g. collagen, ADP, TXA2, thrombin etc.), aggregation via activated platelet GPIIb‐IIIa binding to fibrinogen, fibrin, VWF and fibronectin, and procoagulant thrombin amplification for enhanced fibrin generation.3, 83, 84, 85. Here, VWF is linked to Arterial thrombosis.