Additionally, hormone receptor treatments are a major component of breast cancer therapy and although their specific role in driving hypertensive deaths is uncertain, they are known to increase cardiovascular morbidity and mortality amongst cancer survivors.36 A further consideration is the change in definition of hypertension proposed by the American College of Cardiology/American Heart Association in 2017,37 which lowered the threshold for diagnosis. The gene discussed is NR4A1; the disease is breast carcinoma.