GSDMD and cancer: There are some studies indicating that certain drugs or molecules could trigger GSDMD-mediated pyroptosis in various types of cancer.16,17,28 In our studies, we analyzed the expression of GSDMD in different leukemia cells, and we found that GSDMD expression was not detected in curcumin-insensitive K562 and HL60 cells, while it was high in curcumin-sensitive U937 and other leukemia cell lines.