Since the ability of NLRP1 to form an inflammasome complex was described in 2002, it is now clear that other members of the NLR and ALR family, including NLRP3, NLRC4, and AIM2, can also assemble the inflammasome.24 Emerging evidence indicate that human NLRP2, NLRP7, IFI16, and Pyrin also activate caspase 1.25 In leukemia cells, we found that curcumin promote the expressions of AIM2, IFI16, and NLRC4 but not NLRP1 and NLRP3. The gene discussed is IFI16; the disease is leukemia.