CARD8 and acute myeloid leukemia: Recent studies found that the expression of some pyroptotic inflammasomes and gasdermins decreased in cancer cells.14,15 Drug-regulated pyroptosis promotes inflammatory cell death of cancer and inhibits proliferation and migration of cancer cells.16,17 Val-boroPro, the ‘inflammasome’ sensor protein CARD8 activator, which successively activates procaspase-1 to mediate pyroptosis in primary acute myeloid leukemia (AML) samples and most AML cell lines,18 suggesting that pyroptosis is suitable for the treatment of AML.