E2F4 and cancer: LncRNA GAS5 was also recognized as the important driver of chemoresistance in many cancers, upregulated lncRNA GAS5 enhanced chemosensitivity and cell apoptotic death of triple-negative breast cancer cells, and inhibited DDP-resistance through the lncRNA GAS5-E2F4-PARP1-MAPK axis in epithelial ovarian cancer [24–26].