Furthermore, BMPR‐II protein and mRNA levels are reduced in rat models of PAH induced by hypoxia, monocrotaline (MCT), or Sugen(SU5416)‐hypoxia (SuHx)33, 34 and genetically modified mice carrying human BMPR2 mutations develop PAH.35, 36. This evidence concerns the gene BMPR2 and pulmonary arterial hypertension.