In AD, the accumulation of Aβ has been shown to cause exaggerated translational suppression (Beckelman et al., 2019; Ding et al., 2005; Hernández‐Ortega et al., 2016; Langstrom et al., 1989; Oliveira et al., 2021; Radford et al., 2015; Sajdel‐Sulkowska & Marotta, 1984), in part through phosphorylation of eIF2α (Ma et al., 2013). This evidence concerns the gene EIF2A and Alzheimer disease.