In addition to its angiogenic activity, VEGF potently induces vascular permeability through the VEGFR2 (VEGFR; vascular endothelial growth factor receptor) receptor‐mediated alterations of vascular fenestration and interendothelial junction.[30] I propose that, in the COVID‐19‐infected lung tissue, high levels of VEGF instigates plasma extravasation, leading to pulmonary edema (Figure 1). The gene discussed is VEGFA; the disease is pulmonary edema.