Recently, we have shown that the transgenic mice overexpressing of PHB1 or mutant PHB (PHB1Tyr114Phe or mPHB1) from the fatty acid binding protein-4 (Fabp4) gene promoter (for an adipocyte-specific expression) develops obesity, which is mediated through upregulating mitochondrial biogenesis in adipocytes (Ande et al., 2014, 2016a, 2016b). The gene discussed is PHB1; the disease is obesity due to melanocortin 4 receptor deficiency.