PHB1 and obesity due to melanocortin 4 receptor deficiency: For example, we have shown that transgenic mice overexpressing PHB1 in adipocytes develop obesity, which involves mitochondrial biogenesis (Ande et al., 2014), and others have reported that PHB1 has a role to play in mitochondrial phospho-lipid homeostasis in different model organisms (Merkwirth et al., 2008; Osman et al., 2009a, 2009b).