Within the frameworkof the present study, we conducted the association analysis of six SNPs in the genes that encod proteins involvedin inf lammatory response regulation in the central nervous system (CRP rs3093077, IL1А rs1800587, IL1B rs16944,TNF/ LTA rs1041981, rs1800629, and P2RX7 rs2230912), with nonverbal intelligence in mentally healthy young adultsaged 18– 25 years without cognitive decline with inclusion of sex, ethnicity and the presence of the “risky” APOE ε4 alleleas covariates. This evidence concerns the gene IL1B and Mental deterioration.