INS and obesity due to melanocortin 4 receptor deficiency: According to our data, estradiol given to OVX obese femalesreduced body and adipose tissues weights, the totalnumber of calories consumed, fed insulin plasma level, andfasting glucose blood level and increased glucose tolerance.These observations agree with the generally accepted opinionas to the effect of estradiol on these parameters in femalemice with obesity (Riant et al., 2009; Yan et al., 2019).