Significantly lower occurrence of TCF7L2 (103894T ) andTCF7L2 (53341T ) alleles associated with DM2 and othermetabolic disorders in the samples of indigenous Siberianpeoples compared to Russians was demonstrated, which agreeswith their lower susceptibility to metabolic disorders, includingDM2, compared to the newcomer Caucasian populationdescribed in the literature. This evidence concerns the gene TCF7L2 and metabolic disease.