The established model of CKD‐induced vascular calcification in the rat therefore uses high doses of alfacalcidol and dietary phosphate.(16, 25, 34, 35, 90) In this model of CKD‐induced vascular calcification, hormonal levels are responding to not only uremia but also to the treatment with active vitamin D analog, and so plasma level of PTH is suppressed and FGF23 is highly increased as previously shown in the same model.(16, 25, 34, 35). The gene discussed is FGF23; the disease is chronic kidney disease.