The role of circulating sclerostin on bone metabolism is not clarified, partly due to the rather contradictory finding of a positive association between plasma sclerostin and bone BMD in both CKD and population cohorts.(48, 71, 72, 73, 74, 75, 76, 77) Still, the studies all point toward an involvement of disturbed Wnt pathway in bone disorders in CKD. The gene discussed is SOST; the disease is chronic kidney disease.