A study found that in Murphy Roths Large (MRL)/lpr mice, a spontaneous lupus-like disease model, the reduction of IL-10+ Breg cells and serum IL-10 were accompanied by reduced serum IL-35, prompting that IL-35 may be involved in the regulatory function of Breg cells from lupus [37]. This evidence concerns the gene IL10 and systemic lupus erythematosus.