Previous studies exhibit that Tollip shows significant ubiquitination change in Hepatitis B virus (HBV)-integrated HepG2.2.15 model cell line compared with HepG2 group such that HBV infection remains the leading cause of HCC, while the expression of Tollip is closely correlated with the hepatic Ischemia-Reperfusion process and Tollip deficiency increases liver steatosis [17,28,29]. Here, TOLLIP is linked to hyperinsulinemic hypoglycemia, familial, 4.