EBI3 and infection: Here, we report that the lesions of lungs, the protein expression levels of both EBI3 and p35, as well as the number of iTr35 cell subset were respectively increased in C57BL/6 male mice injected with Mtb H37Ra at 8 week post-infection and enhanced serum IL-35 level was observed in mice at 4 or 8 weeks post-infection.