To meet that end, we investigated the correlation between plasma levels of pro- and anti-inflammatory cytokines, chemokines, Transthyretin (TTR), and amyloid species with cognitive functions and neuropsychiatric symptoms assessed through mini-mental state examination (MMSE), AD assessment scale-cognitive subscale (ADAS-cog), clinical dementia rating (CDR), and neuropsychiatric inventory–questionnaire (NPI-Q). This evidence concerns the gene TTR and Alzheimer disease.