GCSAM and diffuse large B-cell lymphoma: Additionally, Huang et al. [78] provided that overexpression of miR-155 downregulated both the transcription and translation of p85α, which was a negative regulator of the phosphatidylinositol 3-kinase- (PI3K-) AKT pathway in DLBCL, while Li et al. [79] proved that miR-155 could also directly downregulate the specific human germinal center-associated lymphoma (HGAL) gene in the germinal center, thereby reducing the activation of ras homolog family member A (RhoA), increasing the migration ability of lymphoma cells, and promoting the metastasis and infiltration of DLBCL.