Matsubara et al. [17] established an animal myocardial ischemia–reperfusion model and showed that the infusion of GLP-1 and human transferrin could significantly prolong the half-life of the drug and improve the wall motion score index and the left ventricular ejection fraction, confirming that GLP-1 intervention could significantly reduce the infarct size, improve the wall motion index and left ventricular ejection fraction after reperfusion, and ameliorate myocardial reperfusion injury. The gene discussed is GCG; the disease is myocardial ischemia.