JUN and central nervous system cancer: Thus, in GAMG and U-87 MG glioma cells, the SP/NK-1R system (e.g., via a SP-NK-1R complex) could exert an important role in the regulation of DNA expression (intracrine or nucleocrine action) through the modulation of proto-oncogenes and transcription factors (e.g., AP-1, c-myc, c-jun, c-fos, and hypoxia-inducible factor) involved in apoptosis, in cellular differentiation/transformation, and in cell cycle progression [41, 50].