TACR1 and central nervous system cancer: In NK-1R-depleted U-87 MG glioma cells (10 nM of TAC1R siRNA), the population of early apoptotic positive cells was up to 1.8-fold in control sham compared to NK-1R-depleted cells, and the necrotic positive cells were up to 11.9-fold higher in NK-1R-depleted cells compared to control sham.