Studies have proved that M2 TAMs tend to promote directional migration in tumor cells' vessels and invasion by the paracrine loop of tumor-derived CSF-1 and TAM-derived EGF/EGF-like ligands [44, 45], secrete osteonectin [46], Cathepsin [47], and TGF-Beta [48]. The gene discussed is CTSS; the disease is neoplasm.