REN and hypertensive disorder: Moreover, the pathophysiological pathways involved in the impacts of sleep behaviors on hypertension and other cardiometabolic dysfunctions might be overlapped (35), that mainly included systemic inflammation (36), vascular endothelial dysfunction and oxidative stress (37), stimulation of the renin-angiotensin-aldosterone system (38), and altered tone of the sympathetic nervous system (39), the latter of which might also impact the nighttime blood pressure and cause the non-dipping pattern (40).