TLR4 and cardiovascular disorder: The sum of noxious events occurring in TLR4 imparity at different cell populations represent the majority of the causes associated to the related dysfunction; however, in the cardiovascular system, the involvement of other cells expressing TLR4, e.g., endothelium, cardiomyocytes, as well as other anatomical structures important for cardiac dynamics, plays a role on the pathophysiology of cardiovascular diseases (45, 56).