Advances in HSP60 immune system network suggest that the peptides derived from this protein may also be helping to alleviate the inflammatory TLR4-related effects, as peptides derived from this protein have reported to have anti-inflammatory effects with promising results on autoimmune and cardiovascular diseases, which are pathologies where TLR4 also represents a key role (18, 19, 59, 60). Here, HSPD1 is linked to cardiovascular disorder.