To assess the effect of HDAC9 risk variant on vascular cell phenotypes, we compared two hiPSC lines carrying the stroke risk homozygous variant rs2107595 (HDAC9v-1 and HDAC9v-2) in the 3 UTR of HDAC9 with three wild-type (WT) hiPSC lines from healthy individuals, which were used as controls (Figure 1A and Supplementary Table 1) (14). Here, HDAC9 is linked to Stroke.