Here, we developed a human induced pluripotent stem cell (hiPSC) model for the GWAS locus in the Histone Deacetylase 9 (HDAC9) gene region, which has been most strongly associated with ischemic stroke, to assess phenotypic and molecular changes and test inhibitors for potential therapeutic interventions (4). The gene discussed is HDAC9; the disease is ischemic stroke.