As is known, the expression of LOXL3 was detected mainly in the nucleus correlated with tumor invasion, lymph node metastasis, and poorer prognosis of patients (Kasashima et al., 2018) through interacting with SNAIL and contributing to proliferation and metastasis by inducing epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma cells (Eiseler et al., 2012). This evidence concerns the gene LOXL3 and pancreatic ductal adenocarcinoma.