Moreover, the prevalence of TPOAb positivity and SCH tended to be higher in the UIC more than or equal to 250 μg/L group compared with the iodine sufficient group, although the difference was non-significant, suggesting that thyroid autoimmunity may damage thyroid function due to increased iodination of thyroglobulin or direct stimulation of immune cells (20). This evidence concerns the gene TG and spindle cell hemangioma.