• Cluster 1 - Liver fluke-related - ARID1A, BRCA1/2, and TP53 mutations - ERBB2 amplification - CpG island hypermethylation• Cluster 2 - Partly liver-fluke-related - TP53 mutation - High expression of CTNNB1, WNT5B and AKT1• Cluster 3 - High CNA burden - Enriched immune-related pathways• Cluster 4 - Associated with viral hepatitis - BAP1 or IDH1/2 mutation - High expression of FGFR family proteins - CpG shore hypermethylation - Favorable prognosis. This evidence concerns the gene CTNNB1 and animal viral hepatitis.