MAPK8 and ischemia: RGS14 acts as a scaffolding protein that integrates the G protein, Ras/extracellular signal-regulated kinase (ERK), and calcium/calmodulin signaling pathways essential for spine plasticity and cell signaling (52); RGS14 may also reduce hepatic ischemia–reperfusion injury mainly through its interaction with TAK1 and the JNK/p38 signaling axis (53).