IFIH1 and dermatomyositis: Besides anti-synthetase autoantibodies, the autoantibody recognizing melanoma differentiation-associated gene 5 (anti-MDA5) is of the greatest concern as a DM-specific autoantibody, since it delineates a unique clinical phenotype of DM with a high risk of life-threatening lung complications but the signs of myositis are mild or absent (5).