Next, another multivariate Cox regression was performed to adjust potential confounders including age, sex, smoking, differential medications between the survivors and the non-survivors, and CRP ≥ 0.8mg/dL which was recently reported as an independent risk factor (16), which showed that fever, ferritin ≥ 1,250 μg/L, and positive CEA were still independent risk factors for 6-month all-cause mortality in patients with anti-MDA5-positive DM (p < 0.05, Figure 3C). This evidence concerns the gene CRP and dermatomyositis.