The IC50 values of Juglone for inhibiting cell growth were 1.38 μM for CD44+CD133+ tumor-initiating Caco-2 cells and 1.21 μM for ΔCD44+CD133+ non-tumor-initiating Caco-2 cells (Figure 5H), suggesting Juglone is a small-molecule compound targeting CD44+CD133+ cells to inhibit their tumorigenic tendency. Here, PROM1 is linked to neoplasm.