TRPM1 and early-onset autosomal dominant Alzheimer disease: Fan et al. (2016) observed that miR-211-5p impaired neurite differentiation, decreased neuronal viability and accelerated the progression of β amyloid-induced pathologies in mouse cerebral cortices. The TRPM1 protein in mouse brain has a functional relevance in modifying synaptic plasticity (Gebhardt et al., 2016). Expression of Trpm1 mRNA or protein was increased in hypothalamus of immobilization-stressed mice (Lee et al., 2005), in the transgenic Alzheimer’s disease mouse models (Yin et al., 2017), and in brain of mice showing increased ALB (Schmidt et al., 2019).