Patients are predisposed to a wide spectrum of clinical presentations, such as ventricular arrhythmia and SCD, which are associated with mutations in desmosome genes, such as plakoglobin (JUP), desmoplakin (DSP), plakophilin 2 (PKP2), desmoglein 2 (DSG2), and desmocollin 2 (DSC2) (Romero et al., 2013; Corrado et al., 2017). Here, DSC2 is linked to Ventricular arrhythmia.