We also revealed six oncogenes that have been validated to be related to the poor prognosis of patients with cancer: CTSE, CALM1, PHGDH, IL9R, and CD96 (Boulay et al., 2001; Possemato et al., 2011; Yan et al., 2011; Pontious et al., 2019; Salazar et al., 2020; Zhao et al., 2020; Liu et al., 2021). Here, CTSE is linked to cancer.