The expression of 8 hub genes associated with survival time in CM and normal tissues was analyzed in the TCGA- GTEx gene expression dataset and the validation results showed that a total of seven genes showed consistent expression trends in TCGA and GEO datasets, except for CERS6 (CERS6 was up-regulated in CM samples of TCGA dataset and down-regulated in CM samples of GEO dataset) (Figure 7). This evidence concerns the gene CERS6 and cutaneous mastocytosis.