The results showed that among these top genes, the expression levels of GMPR, MLPH, EMP3, SLC45A2 TYR, PAIP2B, GIPC2, PDZD2, NPY1R, DLG5, ADH1B, BARD1 and CERS6 was closely related to the survival time of CM patients, with statistically significant differences (p < 0.05). The gene discussed is EMP3; the disease is cutaneous mastocytosis.