NPY1R and Familial prostate cancer: Many evidences show that the expression of NPY1R gene is up-regulated in various types of nerve or endocrine related cancers (including breast cancer, prostate cancer, adrenal tumor, renal cell cancer and ovarian cancer, etc.), (Kitlinska et al., 2005; Ruscica et al., 2006; Körner et al., 2008; Lv et al., 2016).