The canonical restriction factors include catalytic polypeptide 3G (APOBEC3), APOBEC3F, bone marrow stromal cell antigen 2 (BST-2), tripartite motif-containing 5α (TRIM5α), and sterile alpha motif and HD-domain-containing protein 1 (SAMHD1), which are stimulated by IFNs and produced by cells after viral infection (Ghimire et al., 2018). Here, BST2 is linked to viral infectious disease.