Meanwhile, the up-regulated genes in Cluster 3 were significantly related to adherens junction, axon guidance, Breast cancer, EGFR tyrosine kinase inhibitor resistance, Hedgehog signaling, Human papillomavirus infection, Insulin signaling, Neurotrophin signaling, PI3KAkt signaling, Parathyroid hormone synthesis, secretion and action, Phosphatidylinositol signaling system, phospholipase D signaling (Figure 6C). Here, INS is linked to human papilloma virus infection.