INS and small cell lung carcinoma: Meanwhile, the up-regulated genes in Cluster 2 were significantly related to the cell cycle, cellular senescence, Endocytosis, Focal adhesion, FoxO signaling, Hedgehog signaling, human papillomavirus infection, Inositol phosphate metabolism, Insulin resistance, Longevity-regulating pathway Notch signaling, Nucleocytoplasmic transport, Phosphatidylinositol signaling system, small cell lung cancer, thyroid hormone signaling, mTOR signaling (Figure 6B).