Patients in C3 NSCLC had the highest sensitivity for Temsirolimus (PI3K/MTOR signaling), BIBW2992 (EGFR signaling), Erlotinib (EGFR signaling), PD.0332991 (CDK4/6 inhibitor), CGP.60474 (CDK inhibitor), and Gefitinib (EGFR signaling) with the lowest IC 50 value. Here, CDK4 is linked to non-small cell lung carcinoma.