However, according to our research, this is the first study to suggest that Let-7a may pair with Yap1. Yap1 gene expression and YAP/TAZ protein content did not differ between CT-O and HF-O at baseline, but 48 h after PHx, both Yap1 expression and YAP/TAZ content were lower in the liver of HF-O, which would be consistent to Let-7a increasing. The gene discussed is YAP1; the disease is hydrops fetalis.