Xiao et al. (2005) suggested that the product of the Nf2 gene inhibits cell cycle progression through Cyclin D1 suppression since Nf2 gene silencing results in upregulation of cyclin D1 and S-phase entry. We have shown that despite cyclin D1 showing a tendency to decrease in the HF-O group 48hs after PHx, the protein content still increases greatly in comparison to the baseline, being similar to the CT-O group and allowing the cell to enter the S-phase of the cycle, even with some delay (Fante et al., 2021). Here, CCND1 is linked to hydrops fetalis.