IL-6, a typical inflammatory mediator, works by interfering with degrading enzymes, which can change the level, structure, type, and function of biomacromolecules such as elastin, proteoglycan, and collagen in the IVD matrix, resulting in the AF showing weakened protection and promoting the protrusion of NP from the weak AF. The gene discussed is ELN; the disease is atrial fibrillation.