Additionally, drug resistance of lung cancer cells is also related to β-catenin/survivin, Nrf2/annexina4, etc. Matrine could inhibit the growth of NSCLC cell line H1975 by inhibiting EGFR and inhibiting the activation of the IL-6/JAK1/STAT3 signaling pathway. Here, JAK1 is linked to non-small cell lung carcinoma.