EGFR and cancer: Matrine could inhibit PI3K/Akt/mTOR signaling pathway (Hao et al., 2019), down-regulate the expression of CCR7, EGFR, TMEM16A, down-regulate the ratio of apoptosis-related protein Bcl-2/Bax, inhibit cancer cell proliferation (Xie et al., 2018), migration and invasion (Zhang et al., 2009a), inhibit angiogenesis (Zhou et al., 2012), induce apoptosis (An et al., 2016), and inhibit the xenograft growth in tumor-bearing mice model (Hao et al., 2019).