Matrine could inhibit cell proliferation (Zhou, 2017), metastasis (Kang et al., 2019), promote apoptosis (Zhou, 2017), and inhibit the xenograft growth of human hepatoma cell line HepG2 in tumor-bearing mice model, which was related to inhibiting ERK signaling pathway (Liu et al., 2017), inhibiting the expression of miRNA-122, livin and survivin genes (Zhou, 2017), activating cysteine protease independent pathway and promoting programmed cell death (Zhou et al., 2014b). This evidence concerns the gene BIRC5 and neoplasm.