HIF1A and hepatocellular carcinoma: Under hypoxia, Matrine could inhibit the cell migration of human hepatoma cell lines BEL7402 and SMMC-7721, inhibit the xenograft growth of in hepatoma tumor-bearing mice model, which was attributed to up-regulating the expression of mir-199a-5p to induce HIF-1α downregulation, followed to activate EMT (Dai et al., 2021a).