In addition, Man expression in the renal tubular epithelium upon infection was significantly lower in C5ar1-/- mice compared with WT mice, and Man expression in murine and human RTEC was upregulated by C5a stimulation, suggesting a role of C5aR1 in regulation Man expression in renal tubular epithelial cells (Li et al., 2017; Song et al., 2018). This evidence concerns the gene C5AR1 and infection.